Akebia Therapeutics appoints Michael Clayman and Maxine Gowen to its Board of Directors

– USA, MA – Akebia Therapeutics, Inc. (NASDAQ:AKBA), a biopharmaceutical company focused on harnessing the potential of hypoxia-inducible factor (HIF) biology to develop and commercialize novel therapeutics to treat kidney disease, today announced that Michael D. Clayman, M.D., Chief Executive Officer of Flexion Therapeutics, Inc., and Maxine Gowen, Ph.D., President and Chief Executive Officer of Trevena, Inc., have been appointed to the Company’s Board of Directors. In addition, Kim L. Dueholm, Ph.D. will be stepping down from the Board on July 28, 2014, the effective date of Dr. Clayman and Dr. Gowen’s appointments.

“Both Michael and Maxine bring an extraordinary wealth of scientific, medical and business expertise to Akebia’s Board,” said Muneer A. Satter, Chairman of the Board of Directors. “We look forward to leveraging their insights and guidance as we continue to advance our lead program, AKB-6548 for the treatment of anemia related to chronic kidney disease, and build a biopharmaceutical company that can deliver breakthrough therapeutics. We also want to thank Kim for his valuable contributions to Akebia during his time on our Board.”

Dr. Clayman is a Co-Founder of Flexion, and has served as President and Chief Executive Officer since the company’s inception in 2007. Previously, Dr. Clayman served in senior management positions at Eli Lilly and Company (Lilly), most recently as Vice President, Lilly Research Laboratories, and General Manager of Chorus, Lilly’s early-phase development accelerator. Prior to Lilly, Dr. Clayman was an Assistant Professor in the School of Medicine at the University of Pennsylvania, where his research centered on the immunopathogenesis of renal disease. Additionally, Dr. Clayman is the recipient of the Physician Scientist Award from theNational Institutes of Health.

Dr. Clayman earned a B.A., cum laude, from Yale University and an M.D. from the University of California, San Diego School of Medicine. Following an internship and residency in Internal Medicine at the University of California, San Francisco Moffitt Hospitals, Dr. Clayman completed clinical and research fellowships in nephrology at the University of Pennsylvania.

“AKB-6548 has the potential to drive a paradigm shift in the treatment of anemia related to chronic kidney disease as a once-daily oral treatment that mimics the body’s natural response to anemia,” said Dr. Clayman. “Having focused on renal disease research for many years, I am well-acquainted with the need for new therapeutic options for patients impacted by anemia related to chronic kidney disease, and believe that AKB-6548 has the potential to be an important advance for these patients.”

Dr. Gowen joined Trevena in 2007 as its founding President and CEO. Prior to this position, Dr. Gowen held a variety of leadership roles at GlaxoSmithKline (GSK) over a period of 15 years. As Senior Vice President for the company’s Center of Excellence for Drug Discovery, she developed an innovative new approach to externalizing drug discovery. Dr. Gowen was previously President and Managing Partner at SR One, the venture capital subsidiary of GSK, where she led its investments in and served on the Board of Directors of numerous companies. Dr. Gowen also previously served as Vice President, Drug Discovery, Musculoskeletal Diseases at GSK, where she was responsible for drug discovery and early development for osteoporosis, arthritis and metastatic bone disease.

Dr. Gowen graduated with a B.Sc. in biochemistry from the University of Bristol, U.K., received a Ph.D. in cell biology from the University of Sheffield, U.K., and received an MBA from the Wharton School of theUniversity of Pennsylvania. Dr. Gowen served on the Board of Directors of Human Genome Sciences until the company’s acquisition by GSK in July 2012, and she currently serves on the Board of Directors of theBiotechnology Industry Organization (BIO).

“I am pleased to join Akebia’s Board at this exciting time in the company’s growth,” said Dr. Gowen. “I look forward to collaborating with the other Board members and the management team as the company advances toward key data milestones, including the data from its ongoing Phase 2b trial of AKB-6548 later this year, which, if positive, will set the stage for a global Phase 3 study for this lead program.”

AKB-6548 is currently in Phase 2b development for the treatment of anemia related to chronic kidney disease in patients who are not dependent on dialysis, with results expected in the fourth quarter of 2014.

About Akebia Therapeutics

Akebia Therapeutics, Inc. is a biopharmaceutical company headquartered in Cambridge, Massachusetts, focused on harnessing the potential of hypoxia-inducible factor (HIF) biology to develop and commercialize novel, proprietary therapeutics to treat kidney disease. Akebia’s lead clinical program, AKB-6548, is a once-daily, oral therapy currently in Phase 2b clinical development for the treatment of anemia related to chronic kidney disease, a serious medical condition that leads to increased morbidity and mortality if left untreated.

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